Publications (2010 - Present)

For earlier publications, see dr. farber's cv

2018

Senda, T., Dogra, P., Granot, T., Furuhashi, K., Snyder, M.E., Carpenter, D.J., Szabo, P.A., Thapa, P., Miron, M., and Farber, D.L. (2018) Microanatomical dissection of human intestinal T cell immunity reveals site-specific changes in gut-associated lymphoid tissues over life. Mucosal Immunology. Epub ahead of print. https://doi.org/10.1038/s41385-018-0110-8

Kumar, B.V., Kratchmarov, R., Miron, M., Carpenter, D., Senda, T., Lerner, H., Friedman, A., Reiner, S.L. and Farber, D.L. (2018) Functional heterogeneity of human tissue resident memory T cells based on dye efflux capacities.JCI Insight. 3: 123568. doi: 10.1172/jci.insight.123568.

Miron, M., Kumar, B.V., Meng, W., Granot, T., Carpenter, D., Senda, T., Chen, D., Rosenfeld, A., Zhang, B., Lerner, H., Friedman, A., Hershberg, U., Shen, Y., Rahman, A., Luning Prak, E.T., Farber, D.L. (2018) Human lymph nodes maintain TCF-1hi memory T cells with high functional potential and clonal diversity throughout life. J. Immunol. 201:2132-2140.

Connors, T.J., Baird, J. S., Yopes, M.C., Zens, K.D., Pethe, K., Ravindranath, T., Ho, S.-H. and Farber, D.L. (2018) Developmental regulation of effector and resident memory T cell generation during pediatric viral respiratory tract infection. J. Immunol. 201:432-439.

Rosenfeld, A.M., Meng, W., Chen, D.Y., Zhang, B., Granot, T., Senda, T., Farber, D.L., Hershberg, U. and Luning Prak, E.T. (2018) Computational Evaluation of B-Cell Clone Sizes in Bulk Populations. Frontiers in Immunol. https://doi.org/10.3389/fimmu.2018.01472

Miron, M., Kumar, B.V., Meng, W., Granot, T., Carpenter, D., Senda, T., Turner, D.L., Goldklang, M., Cvetkovski, F., Paik, D., Trischler, J., Barahona, J., Cao, M., Dave, R., Tanna, N., D’Armiento, J.M., and Farber, D.L. (2018) Biased Generation and in situ activation of lung tissue-resident memory CD4 T cells in the pathogenesis of allergic asthma. J. Immunol. 200:1561-1569. PMCID:PMC5821590

Kumar, B.V., Connors, T. and Farber, D.L. (2018) Human T cell development, localization and function throughout life. Immunity. 48:202-213.

Carpenter, D.J., Matsuoka, N., Granot, T., Kumar, B.V., Senda, T., Thome, J.J.C., Gordon, C.L., Miron, M., Weiner, J., Lerner, H., Friedman, A., Griesemer, A.D., Farber, D.L. (2018) Human immunology studies using organ donors: impact of clinical variations on immune parameters in tissues and circulation. Am. J. Trans. 18:74-88. PMCID:PMC5740015

2017

Zens, K.D., Connors, T., and Farber, D.L. (2017) Tissue compartmentalization of T cell responses during early life. Semin. Immunopath. doi. 39:593-604. PMCID:PMC5743209

Zens, K.D., Chen, J.-K., Guyer, R.S., Wu, F.L., Cvetkovski, F., Miron, M. and Farber, D.L. (2017) Reduced generation of lung-tissue resident memory T cells during infancy. J. Exp. Med. 214:2915-2932. PMCID:PMC5626403

Kumar, B.V., Ma, W. Miron, M., Granot, T., Guyer, R.S., Carpenter, D.J., Senda, T., Ho, S.-H., Lerner, H., Friedman, A.L., Shen, Y., and Farber, D.L. (2017) Human tissue-resident memory T cells are defined by core transcriptional and functional signatures in lymphoid and mucosal sites. Cell Reports. 20:2921-2934. PMCID:PMC5646692 Free Article

Klose, C.S.N., Mahlakõiv, T., Moeller, J. B., Rankin, L.C., Flamar, A.-L., Kabata, H., Monticelli, L.A., Moriyama, S., Garbès Putzel, G., Rakhilin, N., Shen, X., Kostenis, E., König, G.M., Senda, T., Carpenter, D., Farber, D.L. and Artis, D. (2017) The neuropeptide neuromedin 2 stimulates innate lymphoid cells and promotes type 2 inflammation. Nature: 549:282-286.

Snyder, M.E. and Farber, D.L. (2017) Thymic-peripheral crosstalk in lymphodepletion therapy. Am. J. Trans. 17:1970-1971.

Yocum, G., Turner, D.L., Danielsson, J. Barajas, M., Zhang, Y., Xu, D. Harrison, N., Homanics, G., Farber, D.L., and Emala, C. (2017) GABAA Receptor α4 Subunit Knockout Enhances Lung Inflammation and Airway Reactivity in a Murine Asthma Model. Am. J. Physiol.-Lung Cell. Mol. Physiol. 313:L406-L415. PMCID:PMC5582940

Meng, W., Zhang, B., Schwartz, G.W., Rosenfeld, A.M., Ren, D., Thome, J.J.C., Carpenter, D., Matsuoka, N., Granot, T., Farber, D.L., Shlomchik, M.J., Hershberg, U. and Luning Prak, N.T. (2017) An atlas of B cell clonal distribution in the human body. Nat. Biotech. 35:879-884. PMCID:PMC5679700

Granot, T., Senda, T., Carpenter, D., Matsuoka, N., Weiner, J., Gordon, C.L., Miron, M., Kumar, B.V., Griesemer, A., Ho, S.-H., Lerner, H., Thome, J.J.C., Connors, T., Reizis, B., and Farber, D.L. (2017) Dendritic cells display subset and tissue-specific maturation dynamics over human life. Immunity, 46:504-515. PMCID:PMC5415308

Weiner, J., Farber, D., Kato, T. and Sykes, M. (2017) Long-term persistence of innate lymphoid cells in the gut after intestinal transplantation. Transplantation, 101:2449-2454. PMCID:PMC5462871

Gordon, C.L., Miron, M., Thome, J.J.C., Matsuoka, N., Weiner, J., Rak, M., Igarashi, S., Granot, T., Lerner, H., Goodrum, F. and Farber, D.L. (2017) Tissue-reservoirs of T cell immunity in persistent human CMV infection. J. Exp. Med. 214:651-667. PMCID: PMC5339671

Nish, S, Zens, K. D. Kratchmarov, R., Lin,W.-H., Adams,W., Chen,Y.-H., Yen,B., Rothman, N., Bhandoola,A., Xue,H.-H., Farber, D.L. and Reiner, S. (2017) CD4+ T Cell Effector Commitment Coupled to Self-renewal by Asymmetric Cell Divisions. J. Exp. Med. 214:39-47. PMCID:PMC5206501

2016

Thome, J.J.C., Grinshpun, B., Kumar, B.V., Kubota, M., Ohmura, Y., Lerner, H., Sempowski, G.D., Shen, Y. and Farber, D.L. (2016) Longterm maintenance of human naive T cells through in situ homeostasis in lymphoid tissue sites. Sci. Immunol. 1: eaah6506. PMCID: PMC5367636

Zuber J., Shonts, B., Lau, S.-P., Obradovic, A., Fu, J., Yang, S., Lambert, M., Coley, S., Weiner, J., Thome, J.J.C., DeWolf, S., Farber, D.L., Shen, Y., Caillat-Zucman, S., Bhagat, G., Griesemer,A., Martinez,M., Kato, T. and Sykes,M. (2016) Bidirectional intragraft alloreactivity drives the repopulation of human intestinal allografts and correlates with clinical outcome. Sci. Immunol. 1:eaah3732. PMCID:PMC5323244

Murray, A.J., Kwon, K.J., Farber, D.L. and Siliciano, R.F. (2016) The latent reservoir for HIV-1: how immunologic memory and clonal expansion contribute to HIV persistence. J. Immunol. 197:407-417. PMCId:PMC4936486

Zens, K.D., Chen, J.-K. and Farber, D.L. (2016) Vaccine-generated lung tissue-resident memory T cells provide heterosubtypic protection to influenza virus infection. J. Clin, Invest. Insight, 1(10):e85832. doi:10.1172/jci.insight.85832. PMCID: PMC4959801

Connors, T.J., Baird, J. and Farber, D.L. (2016) Viral Bronchiolitis in children (correspondance) N. Engl. J. Med. 374:1791-2.

Farber,D.L., Netea,M., Radbruch,A., Rajewsky,K. and Zinkernagel, R. (2016) Immunological memory: lessons from the past and a look to the future. Nat. Rev. Immunol. 16: 124-8.

Connors, T.J., Ravindranath,T.M., Bickham,K.L., Gordon,C.L., Zhang, F., Levin,B., Baird, J.S. and Farber, D.L. (2016) Airway CD8 T-cells are associated with lung injury during infant viral respiratory tract infection. Amer. J. Resp. Cell and Mol. Biol. 54:822-830. PMCID:PMC4942220

Trischler, J., Shiomi, T., Turner, D.L., Sklepkiewicz, P.L., Goldklang, M.P., Farber, D.L. and D’Armiento, J.M. (2016) Immune Modulation of the T cell Response in Asthma through Wnt10b. Amer. J. Resp. Cell and Mol. Biol. 54:584-93.

Thome, J.J.C., Bickham, K.L., Kubota, M. Ohmura, Y., Matsuoka, N., Gordon, C., Granot, T., Griesemer, A., Lerner, H., Kato, T., and Farber, D.L. (2016) Early-life compartmentalization of T-cell differentiation and regulatory function in mucosal and lymphoid tissues. Nature Medicine. 22:72-77. PMCID:PMC4703455

2015

Zuber, J., Rosen, S., Shonts, B., Sprangers, B., Savage, T., Richman, S., Yang, S., Lau, S.P., DeWolf, S., Farber, D.L., Vlad, G., Zorn, E., Wong, W., Emond, J., Levin, B., Martinez, M., Kato, T., Sykes, M. (2015) Macrochimerism in intestinal transplantation: association with lower rejection rates and multivisceral transplants, without GVHD. Am. J. Transplant. 15:2691-703.

Yu, M., Owens, D.M., Ghosh, S. and Farber, D.L. (2015) Conditional PDK1 ablation promotes epidermal and T cell-mediated dysfunctions leading to inflammatory skin disease. J. Invest. Derm. 135: 2688-96. PMCID:PMC4640961

Thome, J.J.C. and Farber, D.L. (2015) Emerging concepts in tissue-resident T cells: lessons from humans. Trends. Immunol. 36:428-35. PMCID:PMC4491028

Tait Wojno, E.D., Monticelli, L.A., Tran, S.V., Alenghat, T., Osborne, L.C., Thome, J.J., Willis, C., Budelsky, A., Farber, D.L. and Artis, D. (2015) The prostaglandin D2 receptor CRTH2 regulates accumulation of group 2 innate lymphoid cells in the inflamed lung. Mucosal Immunology. 8:1313-23. PMCID:PMC4598246

Brestoff, J.R., Kim, B.S., Saenz, S.A., Stine, R.R., Monticelli, L.A., Sonnenberg, G.A., Thome, J.J.T., Farber, D.L., Lutfy, K., Seale, P., and Artis, D. (2015) Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit diet-induced obesity. Nature, 519:242-6. PMCID:PMC4447235

Zens, K.D. and Farber, D.L. (2015) Memory CD4 T cell responses to influenza virus. Current Topics in Microbiology and Immunology. 386:399-421.

2014

Thome, J.J.C., Yudanin, N.A., Ohmura, Y., Kubota, M., Grinshpun, B., Sathaliyawala, T., Kato, T., Lerner, H., Shen, Y. and Farber, D.L. (2014) Spatial map of human T cell compartmentalization and maintenance over decades of life. Cell. 159:814-28. PMCID:PMC4243051

Camirand, G., Wang, Y., Lu, Y. Wan, Y.Y., Lin, Y., Deng, S., Guz, G., Perkins, D.L., Finn, P.W., Farber, D.L., Flavell, R.A., Shlomchik, W.D., Lakkis, F.G., Rudd, C.E., and Rothstein, D.M. (2014) CD45 Ligation increases antigen-mediated expansion of regulatory T cell by promoting interactions with dendritic cells in vivo. J. Clin. Invest. 124:4603-13. PMCID: PMC4191025

Turner, D.L. and Farber, D.L. (2014) Mucosal resident memory CD4 T cells in protection and immunopathology. Front. Immunol. 5:331 Free article

Subramanian, M., Hayes, C.D., Thome, J.J., Thorp, E., Matsushima, G.K., Herz, J., Farber, D.L., Liu, K., Lakshmana, M. and Tabas, I. (2014) A Multiprotein Complex of Axl, LRP-1, and RanBP9 Mediates Dendritic Cell Efferocytosis and Antigen Cross-Presentation In Vivo. J. Clin. Invest. 124:1296-308. Free article

Turner, D.L., Gordon, C.L. and Farber, D.L. (2014) Tissue resident T cells, in situ immunity and transplantation. Immunol. Reviews. 258:150-166.

Farber, D.L. , Yudanin, N.A. and Restifio, N.P. (2014) Human Memory T cells: generation, compartmentalization and homeostasis. Nature Reviews Immunology. 14:24-35. (featured on cover) PMCID:PMC4032067

Turner, D.L., Bickham, K.L., Thome, J.J.T., Kim, C., D’Ovidio, F., Wherry, E.J. and Farber, D.L. (2014) Lung resident niches for the generation and maintenance of influenza-specific memory T cells. Mucosal Immunology. 7:501-10.

2013

Siracusa, M.C., Saenz, S.A., Tait Wojno, E.D., Kim, B.S., Osborne, L.C., Ziegler, C.G., Benitez, A.J., Ruymann, K.R., Farber, D.L., Sleiman, P.M., Hakonarson, H., Cianferoni, A., Wang, M.-L., Spergel, J.M., Comeau, M.R., and Artis, D. (2013) TSLP-mediated extramedullary hematopoiesis promotes allergic inflammation. Immunity. 39:1158-70.

Turner, D.L., Bickham, K.L., Farber, D.L. and Lefrancois, L. (2013) Splenic priming of virus-specific CD8 T cells following influenza infection. J. Virol. 87:4496-506.

Sathaliyawala, T., Kubota, M., Yudanin, N., Turner, D., Camp, P., Thome, J.C., Bickham, K.L., Lerner, H., Goldstein, M., Sykes, M., Kato, T and Farber, D.L. (2013) Distribution and compartmentalization of human circulating and tissue-resident memory T cells. Immunity. 38: 187-197. (Also see preview article in same issue by Neuenhahn and Busch, D.H., “Whole body anatomy of human T cells”. Immunity. 38:10-12.)

2012

Lindqvist, M., van Lunzen, J., Soghoian, D.Z., Kuhl, B.D., Ranasinghe, S., Kranias, G., Flanders, M, Cutler, S., Yudanin, N., Muller, M.I., Davis, I., Farber, D.L., Hartjen, P., Haag, F., Alter, G., Schulze zur Wiesch, J. and Streeck, H. (2012) Expansion of HIV-specific TFH cells is associated with skewing of B cell subsets in chronic HIV infection. J. Clin. Invest. 122(9):3271-80.

Sonnenberg G.F., Monticelli, L.A., Alenghat, T., Fung T.C., Hutnick, N.A., Kunisawa, J., Shibata, N., Grunberg, S., Sinha, R., Zahm, A.M., Tardif, M.R., Sathaliyawala, T., Kubota, M., Farber, D.L., Collman, R.G., Shaked, A., Fouser, L.A., Weiner, D.B., Tessier, P.A., Friedman, J.R., Kiyono, H., Bushman, F.D., Chang, K.M., Artis, D.. (2012) Innate lymphoid cells orchestrate anatomical containment of lymphoid-resident commensal bacteria and prevent systemic immune activation. Science. 336:1321-5.

Shi, Q., Lees, J.R., Scott, D.W., Farber, D.L., and Bartlett, S.T. (2012) Endogenous expansion of regulatory T cells leads to long-term islet graft survival in diabetic NOD mice. Am. J. Trans. 12:1124-32.

2011

Monticelli, L.A., Sonnenberg, G.F., Abt, M. C., Alenghat, T., Ziegler, G.K., Doering, T.A., Angelosanto, J.M., Laidlaw, B.J., Yang, C.Y., Sathaliyawala, T., Kubota, M., Turner, D., Diamond, J.M., Goldrath, A.W., Farber, D.L., Collman, R.G., Wherry, E.J., and Artis, D. (2011) Innate lymphoid cells promote lung tissue homeostasis following acute influenza virus infection. Nature Immunol. 12:1045-54.

Teijaro, J.R., Turner, D., Nam, Q., Wherry, E.J., LeFrançois, L. and Farber, D.L. (2011) Cutting Edge: Tissue-retentive lung memory CD4 T cells mediate optimal protective responses to influenza. J. Immunol. 187:5510-14.

Wilkinson, K., Anderson, B.E., McNiff, J.M., Demetris, A.J., Farber, D.L., Caton, A., Shlomchik, W.D., Shlomchik, M.J. (2011) A Repertoire Independent and Cell Intrinsic Defect in GVHD Induction by Effector Memory T Cells. Blood. 118:6209-19.

Yu, M., Qi, X., Moreno, J.L., Farber, D.L. and Keegan, A.D. (2011) NF-κB signaling participates in both Receptor Activator of NF-κB Ligand- (RANKL) and interleukin-4- (IL-4) induced macrophage fusion: Receptor cross-talk leads to alterations in NF-κB pathways. J. Immunol. 187:1797-806

Ayala, V. I. Ayala, Teijaro, J.R., Farber, D.L., Dorsey, S.G., Carbonetti, N.H. (2011) Bordetella pertussis Infection Exacerbates Influenza Virus Infection through Pertussis Toxin Activity. PLOS One, 6: e19016.

Anderson, B.E., Tang, A.L., Wang, Y., Froicu, M., Rothstein, D., McNiff, J.M., Demetris, A.J., Farber, D.L., Shlomchik, W.J., Shlomchik, M.J. (2011) Enhancing alloreactivity does not restore GVHD induction but augments skin graft rejection by CD4 effector memory T cells. Eur. J. Immunol. 41:2782-92.

Fousteri, G. Dave, A., Juedes, A., Juntti, T., Morin, B., Togher, L., Farber, D.L. and von Herrath, M.G. (2011) Increased memory conversion by naïve CD8 T cells activated during late phases of acute virus Infection. PLOS One. 6:e14502.

Shirey, K.A., Nhu, Q., Yim, K.C., Roberts, Z.J., Teijaro, J.R., Farber, D.L., Blanco, J.C., and Vogel, S.N. (2011) The Anti-tumor Agent, 5,6-Dimethylxanthenone-4-Acetic Acid (DMXAA), induces IFN-β-mediated Antiviral Activity in vitro and in vivo. J. Leuk. Biol. 89:351-7.

Lai, W., Yu, M., Okoye, F.I., Keegan, A.D. and Farber, D.L. (2011) Transcriptional control of rapid recall in Memory CD4 T cells. J. Immunol. 187: 133-40.

2010

Teijaro, J.R., Verhoeven, D., Page, C.A. and Farber, D.L. (2010) Memory CD4 T cells Direct Protective Responses to Influenza Virus in the Lung through Helper-independent Mechanisms. J. Virol. 84:9217-26. (selected for editors’ spotlight feature)

Lees, J.R. and Farber, D.L. (2010) Generation, Persistence and Plasticity of CD4 T cell memories. Immunology. 130:463-70.

Cockburn, I. A., Yun-Chi Chen, Y.-C., Overstreet, M.G., Lees, J.R., van Rooijen, N., Farber, D.L., and Zavala, F. (2010) Persisting antigen is required for optimal CD8+ T cell responses against malaria liver stage parasites. PLOS Pathogens. 6:e1000877

Bushar, N.D., Corbo, E., Schmidt, M., Maltzman, J.S. and Farber, D.L. (2010) Ablation of SLP-76 signaling after T cell priming generates memory CD4 T cells impaired in steady-state and cytokine-driven homeostasis. Proc. Nat’l. Acad. Sci. U.S.A. 107:827-831.

Nhu, Q.M., Shirey, K., Teijaro, J.R., Farber, D.L., Netzel-Arnett, S., Antalis, T.M., Fasano, A., Vogel, S.N. (2010) Novel signaling interactions between proteinase-activated receptor 2 and Toll-like receptors in vitro and in vivo. Mucosal Immunol. 3:29-39.